Guanine nucleotide–binding protein G(i)α2 aggravates hepatic ischemia-reperfusion injury in mice by regulating MLK3 signaling

What is it about?

Hepatic ischemia/reperfusion (I/R) injury often occurs during liver transplantation and resection. Liver I/R injury not only contributes to early functional failure, but also increases the prevalence of both acute and chronic rejection. Exploring molecular mechanism of liver I/R injury will contribute to prevention of hepatic I/R-induced injury and related liver diseases. Our study showed that GNAI2 protein plays a crucial role in hepatic I/R injury. GNAI2 ablation deceases the hepatocyte death and inflammatory infiltration after I/R challenge. Our data demonstrates that GNAI2 may be a potential gene therapy target for the treatment of liver I/R injury.

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