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Bacterial protein toxins cause severe diseases by killing human cells independently from the bacteria. Therefore, a combination of antibiotics and toxin inhibitors is required for therapy against toxin-producing bacteria. We report that the cell wall synthesis-inhibiting antibiotic bacitracin neutralizes bacterial toxins including those from C. difficile and B. anthracis by specifically inhibiting their transport subunits.
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This page is a summary of: Revisiting an old antibiotic: bacitracin neutralizes binary bacterial toxins and protects cells from intoxication, The FASEB Journal, April 2019, Federation of American Societies For Experimental Biology (FASEB),
DOI: 10.1096/fj.201802453r.
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