The α/β–hydrolase domain 6 inhibitor WWL70 decreases endotoxin-induced lung inflammation in mice, potential contribution of 2-arachidonoylglycerol, and lysoglycerophospholipids

What is it about?

In this manuscript, we describe how by blocking the function of an enzyme we decrease the acute inflammation that develops in the lungs. To do so, we have used a mouse model mimicking acute lung inflammation in humans. The enzyme we studied, namely the α/β-hydrolase domain 6, regulates the levels of 2-arachidonoylglycerol, a lipid mediator that has anti-inflammatory properties. Our results could have broad implications has lipid mediators are important players in the control of inflammation.

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