Calorie restriction reprograms diurnal rhythms in protein translation to regulate metabolism

What is it about?

It is recognized that diet significantly affects the physiology and metabolism. "Bad" diet might contribute to the development of diseases while "good" diet might promote health. One well-known diet with recorded health and longevity benefits is Calorie Restriction (CR), but it is not well known how does CR work. Circadian clock attracted recently attention as an important regulator of metabolism. It was found that circadian rhythms contribute to the effect of CR on metabolism. In the current study we investigated the effect CR on mRNA translation in the liver of mice across the day and found that CR completely reprogramed the circadian rhythms in protein translation. The translation of many proteins, which are implicated in the molecular mechanisms of CR was affected. One of the strongest effects of CR was observed for the translation of proteins that regulate fat metabolism. In summary, our further study unraveled novel molecular pathways and helped to the mechanistic connection between diet, metabolism and gene expression.

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