Differentiation of bone marrow–derived cells toward thermogenic adipocytes in white adipose tissue induced by the β3 adrenergic stimulation

What is it about?

The regulatory roles of thermogenic adipocyte in energy expenditure and body fat content have been widely appreciated in humans. The identification of precursor cells of thermogenic adipocytes is of great interest in terms of understanding thermogenic adipocyte biology because it could lead to recognizing of targetable pathways for the development of novel therapeutics to fight obesity and diabetes. We here identified bone marrow cells as a previously overlooked important source of thermogenic adipocytes. The transdifferentiation of bone marrow-derived cells into thermogenic adipocytes was stimulated by selective activation of β3 adrenergic receptor. Our results unveiled a crucial role of bone marrow cells in thermogenic fat tissue expansion as a non-resident origin for a subset of thermogenic adipocytes.

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