The protein synthesis inhibitor brusatol normalizes high-fat diet–induced glucose intolerance in male C57BL/6 mice: role of translation factor eIF5A hypusination

What is it about?

The naturally occurring plant compound brusatol improves the survival of stressed and damaged insulin-producing cells in a laboratory setting. The aim of the present study was to investigate whether brusatol also promotes beneficial effects in high-fat diet mice, and if so, to study the mechanisms by which brusatol acts. In the mice we observe that the impaired glucose tolerance in response to a high-fat diet was counteracted by a two-week treatment with brusatol. Brusatol treatment improved the peripheral insulin sensitivity of high-fat diet treated mice. The results of the present study suggest that brusatol improves glucose intolerance in high fat diet treated mice, possibly by inhibiting protein biosynthesis and eIF5A hypusination.

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