Müller glia phagocytose dead photoreceptor cells in a mouse model of retinal degenerative disease

What is it about?

Our study demonstrates that Müller cells are responsible for phagocytosing and clearing photoreceptor neurons, whereas microglia, another phagocytic neuroglia found in the retina, play a complementary but more limited role at the early degenerative stage of retinitis pigmentosa. Our study reveals cell biological processes critical for the health of cells in the normal retina, as well as the means of clearing debris during the progression of retinal degeneration.

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