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Loss of sacsin, in the ataxia ARSACS, leads to disorganization of the neurofilament network. This study identified direct roles of sacsin domains in regulating intermediate filament assembly and dynamics, implicating sacsin as an essential factor in maintaining cytoarchitecture.

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This page is a summary of: Sacsin, mutated in the ataxia ARSACS, regulates intermediate filament assembly and dynamics, The FASEB Journal, October 2018, Wiley,
DOI: 10.1096/fj.201801556r.
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