Betaine-homocysteine S-methyltransferase deficiency causes increased susceptibility to noise-induced hearing loss associated with plasma hyperhomocysteinemia

Teresa Partearroyo, Silvia Murillo-Cuesta, Néstor Vallecillo, Jose M. Bermúdez-Muñoz, Lourdes Rodríguez-de la Rosa, Giacomo Mandruzzato, Adelaida M. Celaya, Steven H. Zeisel, María A. Pajares, Gregorio Varela-Moreiras, Isabel Varela-Nieto
  • The FASEB Journal, May 2019, Federation of American Societies For Experimental Biology (FASEB)
  • DOI: 10.1096/fj.201801533r

What is it about?

This paper studies the impact of hyperhomocysteinemia on hearing loss, using a knockout mouse model for one of the enzymes that convert homocysteine in methionine that is BHMT.

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http://dx.doi.org/10.1096/fj.201801533r

The following have contributed to this page: Dr María A Pajares, Isabel Varela-Nieto, and Steven Zeisel