What is it about?
DNA methylation is a crucial epigenetic mechanism in obesity and fat distribution. Here, we explore the methylation and mRNA expression of the Sarcospan (SSPN) gene in human adipose tissue.
Featured Image
Why is it important?
We show that DNA methylation of the SSPN promoter suppresses mRNA expression, which might explain the associations with clinical variables related to fat distribution and glucose metabolism. In line with this, genetic variants in SSPN related to fat distribution are associated with SSPN DNA methylation.
Perspectives
Our data strongly support the role of SSPN in body fat composition and glucose homeostasis, which is most likely attributed to the changes in DNA-methylation of SSPN in adipose tissue, ultimately driven by genetic variants in the locus.
Yvonne Böttcher
University of Oslo, Norway and University of Leipzig, Germany
Read the Original
This page is a summary of: DNA methylation of SSPN is linked to adipose tissue distribution and glucose metabolism, The FASEB Journal, June 2018, Federation of American Societies For Experimental Biology (FASEB),
DOI: 10.1096/fj.201800528r.
You can read the full text:
Contributors
The following have contributed to this page
