Laminin‐dystroglycan signaling regulates retinal arteriogenesis

What is it about?

Proper development of the retinal blood supply is important to assure all retinal cells remain healthy and function normally. Malformation of retinal blood supply either during growth or as result of aging results in a variety of human diseased. This paper addresses the role of proteins outside of cells of the retinal blood vessels in directing the proper development of arteries. It identifies for the first time a novel signaling pathway that mediates arterial identity. This paper opens a new area for understanding how diabetes, inflammation and other pathology can lead to blood vessel changes in the retina.

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