Targeted deletion of T-cell S1P receptor 1 ameliorates cardiac fibrosis in streptozotocin-induced diabetic mice

What is it about?

Diabetic cardiomyopathy (heart injury because of diabetes) is one of the most severe complications for diabetic patients. Our present research indicates that mice without S1P receptor 1 on T cells displayed less fibrosis and better recovery from the stress of hyperglycemia in a murine diabetic model. It may shed light on the drug discovery for cardioprotection for diabetic patients. Comparing with the littermate vehicle control mice, these mice without T cell S1P receptor 1 presented cardiac dysfunction and fibrosis at normal glucose levels.

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Why is it important?

This article reveals the critical role of T cell S1P receptor 1 (S1P1) in diabetic cardiomyopathy. Deletion of T cell S1P1 protects the heart from diabetic injury. Special deletion of T cell S1P1 may shed light on novel target on cardiac protection in diabetic model.

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