Reduction in replication‐independent endogenous DNA double‐strand breaks promotes genomic instability during chronological aging in yeast

What is it about?

In this paper, we report a mechanism how genomic instability occurs in aging non dividing cells. This is significant. Although genomic instability is a hall mark of aging, the mechanism in non-dividing cells has not been known. Understand mechanism of genomic instability in chronological aging will lead to possibility in prevent senescence of many important organ including brain. Here we showed that DNA contains gaps to reduce tension like gaps in a railway train. When cell aged many of these gaps disappear. Consequently, DNA is strained and broken. Finally, the DNA breaks cause cell to be old.

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