What is it about?
The skin of amphibians can be maintained in a healthy and balanced state with rapid and efficient regeneration and scar-less healing. However, the exact mechanism of quick wound healing in amphibians is largely unknown. Various pore-forming proteins (PFPs) have been identified in multiple organisms from all kingdoms of life. They have powerful innate immune weapon and directly kill pathogens by forming transmembrane pores. We reported here that βγ-CAT as an aerolysin-like pore-forming protein identified in the frog can promote scar-less wound healing by initiating early rapid inflammatory responses. This is the first example that aerolysin-like pore-forming proteins may act in wound healing and tissue repairing.
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Why is it important?
Our findings show that βγ-CAT as a pore-forming protein identified from the skin of frog, promoted scar-less healing in mouse models by triggering the acute inflammatory response. It showed a strong ability to promote tissue repairing with rapid epithelialization, resistance to multidrug-resistant bacterial infections and reduction of edema in mice.
Perspectives
I hope this article will help people to understand the role of pore-forming proteins like βγ-CAT in wound healing in amphibians. It is worth to explore its potential medical applications in the future.
Yun Zhang
Kunming Institute of Zoology CAS
Read the Original
This page is a summary of: Pore-forming toxin-like protein complex expressed by frog promotes tissue repair, The FASEB Journal, January 2019, Federation of American Societies For Experimental Biology (FASEB),
DOI: 10.1096/fj.201800087r.
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