What is it about?
Hypothermic oxygenated perfusion (HOPE) is a relatively new dynamic preservation procedure that has not been widely implemented in liver transplantation despite its advantages. In our research, we investigated detailedly the role of Thioredoxin-interacting protein /NOD-like receptor protein 3 inflammasome pathway in the protective mechanisms of HOPE to rat livers donated after cardiac death (DCD).
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Why is it important?
Compared to the cold storage, HOPE reduced liver injury and improved liver function. Our findings also revealed that reperfusion injury induced liver damage and activated the TXNIP/NLRP3 inflammasome pathway in DCD rat livers. Pretreatment of DCD rat livers with HOPE inhibited the TXNIP/NLRP3 inflammasome pathway and attenuated liver ischemia/reperfusion injury (IRI).
Perspectives
We hope our research will make a little contribution to the clinical application promotion of HOPE in liver transplantation, which is of great significance for expanding the source of liver allograft. It will bring hope for many patients with end-stage liver disease who need liver transplantation.
He Weiyang
Wuhan University
Read the Original
This page is a summary of: Hypothermic oxygenated perfusion (HOPE) attenuates ischemia/reperfusion injury in the liver through inhibition of the TXNIP/NLRP3 inflammasome pathway in a rat model of donation after cardiac death, The FASEB Journal, June 2018, Wiley,
DOI: 10.1096/fj.201800028rr.
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