What is it about?
Although significant progress has been made toward understanding the pathogenesis and therapies of acute lung injury (ALI) or its more severe form, acute respiratory distress syndrome (ARDS), but still is associated with high mortality rates reaching 40% to 50%. Clinically, the treatment of ALL/ARDS merely consists of supportive measures and lack of effective treatments that specifically act on ALL/ARDS targets. This study observed the dynamic alterations of the lungs during ALL, and explored the key molecules that leading to ALL occurrence. Our results provide the time course and potential specific molecular targets for ALI treatment, which may greatly decrease the degree of ALL and the mortality rates.
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This page is a summary of: A self-organized actomyosin drives multiple intercellular junction disruption and directly promotes neutrophil recruitment in lipopolysaccharide-induced acute lung injury, The FASEB Journal, June 2018, Federation of American Societies For Experimental Biology (FASEB),
DOI: 10.1096/fj.201701506rr.
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