Dietary genistein supplementation in laying broiler breeder hens alters the development and metabolism of offspring embryos as revealed by hepatic transcriptome analysis

What is it about?

Genistein , the predominant isoflavone derived from soybean, has been investigated for its hypolipidemic, antilipogenic and antioxidant effects in biological systems.Maternal estrogen has a major influence on embryos and newborns. It has been reported that embryonic exposure to isoflavones can influence the developmental programming of the offspring's growth.Dietary GEN can also be deposited into the egg yolk of poultry.The growth period of birds is short, and chick embryos have independent development, which is beneficial for studying the effects of maternal nutrition on embryonic development and metabolism. Thus, we analyze the effects of feeding laying broiler breeder hens with genistein on the development and metabolism of chick embryos, providing a theoretical basis for research on maternal nutrition.We found Feeding genistein to laying broiler breeder hens improved the immune function and antioxidant capacity of their embryonic chicks.Genistein treatment promoted the glycolysis process; the transport of carboxylic acids, lipids and cholesterol; and the synthesis of fatty acids in the embryonic liver.This research is of great significance. As we all know, metabolic diseases such as obesity, diabetes can be passed on to offspring.And isoflavones can also be transported into the embryo through the blood-placenta barrier.Therefore, our finding indcated that the maternal genistein treatment can prevent hereditary diseases related to metabolism and immune function,which can improve the health condition of our offsprings.

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