What is it about?
In this study, we identified that CENP-W interacts with two core components of SCFβ-TrCP1, CUL1 and β-TrCP1, and consequently reduces SCFβ-TrCP1 activity. Remarkably, this interaction is prominent during the G2/M transition, and CDC25A phosphatase, the essential CDK1 activator, substantially reduced in CENP-W knockdown cells. We propose that the new kinetochore component CENP-W may contribute to the timely activation of CDK1 by preventing a premature degradation of CDC25A by SCFβ-TrCP1 ubiquitin ligase at the G2/M boundary.
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Why is it important?
CENP-W inhibits CDC25A degradation by destabilizing the SCFβ-TrCP-1 complex at G2/M. CENP-W participates in cell cycle regulation by modulating SCFβ-TrCP1 ubiquitin ligase activity.
Perspectives
I'd like to thank everyone :)
Yeongmi Cheon
Korea Basic Science Institute
Read the Original
This page is a summary of: CENP‐W inhibits CDC25A degradation by destabilizing the SCF
β‐TrCP‐1
complex at G
2
/M, The FASEB Journal, June 2018, Wiley,
DOI: 10.1096/fj.201701358rrr.
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