What is it about?
In the absence of SPNS2, the disorganization of developing retina is associated with disruption of cell polarity and cell-cycle exit of retinal progenitor cells, and insufficient migration of newborn neurons at the postnatal stage. The underlying mechanisms of this structural disorder are related to SPNS2-induced S1P release and S1PR3 activation in the eye.
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Why is it important?
This is the first study for the functions of SPNS2 in the central nervous system.
Perspectives
This study may inspire follow-up researches regarding functions of SPNS2 in the other parts of CNS, as well as its roles in CNS disorder.
Dr. Chao Fang
Fourth Military Medical University
Read the Original
This page is a summary of: S1P transporter SPNS2 regulates proper postnatal retinal morphogenesis, The FASEB Journal, July 2018, Federation of American Societies For Experimental Biology (FASEB),
DOI: 10.1096/fj.201701116r.
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