Angiogenin and the MMP9‐TIMP2 axis are up‐regulated in proangiogenic, decidual NK‐like cells from patients with colorectal cancer

What is it about?

We found that NK cells in tumor tissues and peripheral blood of patients with colon cancer acquire a pro-angiogenic phenotype and function, suggesting a contribution to colon cancer progression. Using the drug pimozide, an antipsychotic agents that inhibit the STAT/STA% axis, we were able to limit the ability of NK from colon cancer patients to produce pro-angiogenic/pro-tumorigenic factors.

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