Role of the glucocorticoid-induced leucine zipper gene in dexamethasone-induced inhibition of mouse neutrophil migration via control of annexin A1 expression

What is it about?

We identified a new molecular mechanism of the anti-inflammatory drugs "Glucocorticoids". Glucocorticoids (GC) are anti-inflammatory drugs. Their activity is mediated by GILZ, a protein induced by treatment with GC. GILZ up-regulate the anti-inflammatory Annexin-1 that inhibits neutrophils migration and inflammation.

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Why is it important?

The demonstration that GILZ is necessary for Annexin-1 induction and then is a mediator of Glucocorticoids anti-inflammatory activity.