What is it about?
This is the first report demonstrating that EMPs restore the lipid-induced impairment of endothelium-dependent vasodilation and NO production. Moreover, these data point to the possible involvement of Akt/eNOS and Nrf2/ARE pathways in mediating the effects of EMPs on the endothelium. We also suggest when and how EMPs exert pathological or protective effects on the endothelium.
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Why is it important?
EMPs are vectors of paradoxical information in the endothelium with a role in both health and disease, thus, EMP function is dependent on the pathological context, and mechanisms and sites of formation.
Perspectives
Future work will focus on the analysis of EMP content, which may hold unique prognostic information in order to stratify patients for appropriate therapy based on their risk of atherothrombotic disease.
Juan Duarte
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This page is a summary of: Endothelial microparticles prevent lipid-induced endothelial damageviaAkt/eNOS signaling and reduced oxidative stress, The FASEB Journal, July 2017, Federation of American Societies For Experimental Biology (FASEB),
DOI: 10.1096/fj.201601244rr.
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