What is it about?
In Drosophila, fat body remodeling is an ecdysone-induced process. We have shown that the activated PVR is sufficient to induce fat body remodeling and fat mobilization. Removal of PVR does not prevent fat body remodeling, but causes ecdysone signaling up-regulated. We proposed a dual-secured mechanism that involves an ecdysone-induced fat body remodeling pathway and a reinforced PVR pathway. Ectopic expression of activated c-kit in fat body also results in a similar phenotype.
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Why is it important?
Our findings show for the first time that :a) in Drosophila, activated PVR is sufficient to induce fat body remodeling and tissue remodeling is capable of being decoupled from their normally associated developmental stages. b) c-kit, the mouse homolog of PVR, may has function in lipid metabolism in mammals.
Perspectives
Writing this article was a great pleasure as it is my first time to publish a research paper. This article makes me find it is interesting and exciting to do fundamental research.
Huimei Zheng
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This page is a summary of:
Premature remodeling of fat body and fat mobilization triggered by platelet-derived growth factor/VEGF receptor in
Drosophila
, The FASEB Journal, January 2017, Federation of American Societies For Experimental Biology (FASEB),
DOI: 10.1096/fj.201601127r.
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