ZBED6 negatively regulates insulin production, neuronal differentiation, and cell aggregation in MIN6 cells

What is it about?

This work deals with how the specific transcription factor ZBED6, i.e. a protein that controls how other proteins are synthesised, affects the insulin producing beta cell. We observe, by removing this protein, that ZBED6 makes MIN6 beta cells release less insulin. ZBED6 also hampers cAMP and calcium mobilisation within beta cells, and counteracts beta cell differentiation into a more neuronal like appearance. We conclude that ZBED6 may have a role in preventing premature formation of beta cells and that modulation of ZBED6 levels might be useful for the production of new beta cells.

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