What is it about?
Cells from multiple myeloma patients frequently have rearrangements of chromosome pieces. One such rearrangement between chromosome 4 and 14 found in about 20% of patients increases expression of a gene named MMSET and also a small RNA named ACA11. Here we demonstrate that the small RNA inhibits the cellular system for turning on antioxidant genes. This defect is responsible, at least in part, for cancer cell growth.
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Why is it important?
This report identifies a new mechanism responsible for proliferation of multiple myeloma cells.
Perspectives
I was fortunate to have a small role in this project. Specifically I used chromatin immunoprecipitation to measure NRF2 promoter binding caused by ACA11 overexpression in the presence or absence of ROS.
Dr Richard L Bennett
University of Florida
Read the Original
This page is a summary of: Sabotaging of the oxidative stress response by an oncogenic noncoding RNA, The FASEB Journal, October 2016, Federation of American Societies For Experimental Biology (FASEB),
DOI: 10.1096/fj.201600654r.
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