What is it about?
High cholesterol might harm more than our cardiovascular systems. Our new research using animal models, published online in The FASEB Journal, suggests that high cholesterol levels trigger mitochondrial oxidative stress on cartilage cells, causing them to die, and ultimately leading to the development of osteoarthritis.
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Why is it important?
This research tested the potential therapeutic role of mitochondria targeting antioxidants in high-cholesterol-induced osteoarthritis and provided proof-of-concept for the use of mitochondrial targeting antioxidants to treat osteoarthritis.
Perspectives
Our team has already begun working alongside dietitians to try to educate the public about healthy eating and how to keep cholesterol levels at a manageable level that won't damage joints, in collaboration with orthopedic surgeons based at Prince Charles Hospital, Brisbane Australia.
Mao Xinzhan
Read the Original
This page is a summary of: Protective effects of mitochondria-targeted antioxidants and statins on cholesterol-induced osteoarthritis, The FASEB Journal, October 2016, Federation of American Societies For Experimental Biology (FASEB),
DOI: 10.1096/fj.201600600r.
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Resources
High cholesterol triggers mitochondrial oxidative stress leading to osteoarthritis
Science Daily
High cholesterol triggers mitochondrial oxidative stress leading to osteoarthritis
Eureka Alert
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High Cholesterol Can Cause Bone Loss: Study
Daily-Sun
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