What is it about?
The function of HDL-good cholesterol- may be as important is its quantity. We found that when the main protein of HDL is exposed to primary human macrophages, the protein, apoA-I, was cleaved. This was functionally important and was mediated by an enzyme called cathepsin B. This process may limit the ability of d cholesterol to remove cholesterol from coronary arteries.
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Why is it important?
Improving the function of HDL may help treat coronary disease.
Perspectives
Many prior modifications of HDL have been reported, but they are usually quantitatively minor. The findings of this paper are exciting because there is variation among different donor cells- ie different people- and the amount of cleavage is quantitatively major- up to 80% in 24h. I am a clinical Cardiologist, so finding something that is relevant to human macrophages is very important for human disease.
Prof Leonard Kritharides
ANZAC Research Institute
Read the Original
This page is a summary of: Human macrophage cathepsin B-mediated C-terminal cleavage of apolipoprotein A-I at Ser228 severely impairs antiatherogenic capacity, The FASEB Journal, September 2016, Federation of American Societies For Experimental Biology (FASEB),
DOI: 10.1096/fj.201600508r.
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