What is it about?
This manuscript describes the long-term effects of JNK1 ablation in a mouse model of diet-induced obesity. It shows that JNK1 ablation confers long-term protection from diet-induced obesity and insulin resistance but predisposes to skin oxidative damage
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Why is it important?
The stress-responsive kinase JNK1 plays a major role in the oxidative stress response and in metabolic stress response associated to obesity and type-2 diabetes. Our study investigate the long-term effects of JNK1 ablation in mice model of obesity.
Perspectives
This manuscript indicate that JNK1 is a valuable target for the treatment of obesity-driven insulin resistance, but it also indicate that systemic JNK1 inhibition may predispose to skin oxidative damage.
Giovanni Solinas
Read the Original
This page is a summary of: JNK1 ablation in mice confers long-term metabolic protection from diet-induced obesity at the cost of moderate skin oxidative damage, The FASEB Journal, May 2016, Federation of American Societies For Experimental Biology (FASEB),
DOI: 10.1096/fj.201600393r.
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