What is it about?
We found that galectin-3, a multifunctional protein, binds to inflammasomes and help the formation and activation of inflammasomes. The activation of inflammasomes leads to release of cytokines that causes inflammation. This makes authoimmune liver diseases worse.
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Why is it important?
Our findings suggest that inhibition of galectin-3 or NLPR3 inflammasome could be therapies.
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This page is a summary of: Galectin-3 regulates inflammasome activation in cholestatic liver injury, The FASEB Journal, September 2016, Federation of American Societies For Experimental Biology (FASEB),
DOI: 10.1096/fj.201600392rr.
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