What is it about?
This research article uncovers new mechanisms of how the lungs respond to and protect against oxidant injury.
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Why is it important?
We discovered that a cytokine, Macrophage Migration Inhibitory Factor, and its receptor, CD74 mediate important protective responses of lung endothelial cells.
Perspectives
Identifying lung-protective mechanisms, such as CD74, will promote the discovery of new cures for lung injury and respiratory failure.
Dr Patty J Lee
Yale University
Read the Original
This page is a summary of: Endothelial CD74 mediates macrophage migration inhibitory factor protection in hyperoxic lung injury, The FASEB Journal, January 2015, Federation of American Societies For Experimental Biology (FASEB),
DOI: 10.1096/fj.14-260299.
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