Folic acid deficiency induces premature hearing loss through mechanisms involving cochlear oxidative stress and impairment of homocysteine metabolism

Raquel Martínez-Vega, Francisco Garrido, Teresa Partearroyo, Rafael Cediel, Steven H. Zeisel, Concepción Martínez-Álvarez, Gregorio Varela-Moreiras, Isabel Varela-Nieto, María A. Pajares
  • The FASEB Journal, November 2014, Federation of American Societies For Experimental Biology (FASEB)
  • DOI: 10.1096/fj.14-259283

The deficit in folic acid accelerates hearing loss

What is it about?

The influence of a reduced dietary intake of folic acid on hearing loss is explored. This vitamin deficit accelerates the development of profound hearing loss that are due to severe alterations in cochlear histology. The reduced folic acid intake also alters cochlear homocysteine metabolism and induces oxidative stress.

Why is it important?

Although former epidemiological studies suggested a role for folic acid and high plasmatic homocysteine levels on hearing loss, this is the first demonstration of cochlear effects due to a deficit in this vitamin.

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The following have contributed to this page: Isabel Varela-Nieto and Dr María A Pajares