Decrease in αβ/γδ T‐cell ratio is accompanied by a reduction in high‐fat diet‐induced weight gain, insulin resistance, and inflammation

What is it about?

Immune cells have been shown to play a role in obesity-associated development of insulin resistance. The contribution of different types of T cells (alphabeta versus gammadelta T cells) has not clearly been established. In this study, a mouse model was used that is partially deficient for alphabeta T cells. It was shown that these mice are partially protected against obesity induced by a high fat diet. Furthermore, independent of the effect on weight the mice are more insulin sensitive compared to normal control mice. The livers of these modified mice are also partially protected against high fat diet-induced fatty liver. These protective effects are thought to be largely due to immune cell changes in adipose tissue.

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