Platelet‐derived growth factor‐AA is a substantial factor in the ability of adipose‐derived stem cells and endothelial progenitor cells to enhance wound healing

What is it about?

The study indicated that platelet-derived growth factor-AA might play a vital role in adipose-derived stem cells and endothelial progenitor cells enhancing wound healing, possibly by its effects on angiogenesis. The wound model and wound-healing assay of the study showed that transplantation of ASCs could enhance wound healing. The results showed that the PDGF-AA knock-down ASCs group had much less improvement of wound healing than other groups treated with wild-type ASCs in wound tissues. The regulation of PDGF-AA in ASCs may contribute to improve wound healing through the PI3K/Akt/eNOS signaling pathway. The data indicated that PDGF-AA might play a vital role in ASCs and EPCs enhancing wound healing, possibly by its effects on angiogenesis. It would be a potential approach using PDGF-AA for clinical treatment of chronic wounds.

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