Role of SSPN in adipose tissue distribution and glucose metabolism
What is it about?
DNA methylation is a crucial epigenetic mechanism in obesity and fat distribution. Here, we explore the methylation and mRNA expression of the Sarcospan (SSPN) gene in human adipose tissue.
Why is it important?
We show that DNA methylation of the SSPN promoter suppresses mRNA expression, which might explain the associations with clinical variables related to fat distribution and glucose metabolism. In line with this, genetic variants in SSPN related to fat distribution are associated with SSPN DNA methylation.
The following have contributed to this page: Yvonne Böttcher
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