DNA methylation of SSPN is linked to adipose tissue distribution and glucose metabolism

Maria Keller, Matthias Klös, Kerstin Rohde, Jacqueline Krüger, Tabea Kurze, Arne Dietrich, Michael R. Schön, Daniel Gärtner, Tobias Lohmann, Miriam Dreßler, Michael Stumvoll, Matthias Blüher, Peter Kovacs, Yvonne Böttcher
  • The FASEB Journal, June 2018, Federation of American Societies For Experimental Biology (FASEB)
  • DOI: 10.1096/fj.201800528r

Role of SSPN in adipose tissue distribution and glucose metabolism

What is it about?

DNA methylation is a crucial epigenetic mechanism in obesity and fat distribution. Here, we explore the methylation and mRNA expression of the Sarcospan (SSPN) gene in human adipose tissue.

Why is it important?

We show that DNA methylation of the SSPN promoter suppresses mRNA expression, which might explain the associations with clinical variables related to fat distribution and glucose metabolism. In line with this, genetic variants in SSPN related to fat distribution are associated with SSPN DNA methylation.

Perspectives

Yvonne Böttcher (Author)
University of Oslo, Norway and University of Leipzig, Germany

Our data strongly support the role of SSPN in body fat composition and glucose homeostasis, which is most likely attributed to the changes in DNA-methylation of SSPN in adipose tissue, ultimately driven by genetic variants in the locus.

The following have contributed to this page: Yvonne Böttcher