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Intimal hyperplasia caused by vascular reconstructive surgeries or endovascular procedures is the major cause of vascular restenosis. We examined the expression profile of circular RNA in rat carotid artery balloon injury model and found rno_circ-005717 (circDIAPH3) declined the level of DIAPH3, which regulates the differentiation of vascular smooth muscle cells (VSMCs). The knockdown of circDIAPH3 promotes the differentiation of VSMCs to contractile type. In addition, circDiaph3 up-regulates the level of Igf1r protein as a competing endogenous RNA of miR-148a-5p. This circular RNA may be a novel therapeutic target of intimal hyperplasia.

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This page is a summary of: circDiaph3 regulates rat vascular smooth muscle cell differentiation, proliferation, and migration, The FASEB Journal, February 2019, Federation of American Societies For Experimental Biology (FASEB),
DOI: 10.1096/fj.201800243rrr.
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