A novel immunodeficient rat model supports human lung cancer xenografts

Di He, Junhui Zhang, Wanwan Wu, Ning Yi, Wen He, Ping Lu, Bin Li, Nan Yang, Di Wang, Zhigang Xue, Peng Zhang, Guoping Fan, Xianmin Zhu
  • The FASEB Journal, January 2019, Federation of American Societies For Experimental Biology (FASEB)
  • DOI: 10.1096/fj.201800102rr

SD-RG rat is an innovative solution for establishing human lung cancer PDX

What is it about?

1. Rag1-/-Rag2-/-Il2rg-/Y (SD-RG) rat is a severely immunodeficient model lacking mature T, B and NK cells. 2. SD-RG rats can support fast growth of human lung cancer xenografts, while retaining the histopathological features of the original tumor. 3. SD-RG rats serve as a novel model for oncology research.

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