linc-SCRG1 accelerates liver fibrosis by decreasing RNA-binding protein tristetraprolin

What is it about?

By screening lncRNAs profiles in liver tissues of chronic hepatitis B patients, linc-SCRG1 was found highly expressed in cirrhotic tissues. Our results indicated that low expression linc-SCRG1 suppressed liver fibrosis by limiting reducing RNA-binding protein-tristetraprolin (TTP), which could reverse the effects on the activation of hepatic stellate cells induced by TGF-β1.

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