Response gene to complement 32 suppresses adipose tissue thermogenic genes through inhibiting ß3‐adrenergic receptor/mTORC1 signaling

What is it about?

Fat tissue plays an important role in obesity. It stores excess energy as triglyceride. The classical fat tissue is white adipose tissue. Recent studies found a kind of good fat tissue in human, named brown fat tissue. This kind of fat tissue can spend more energy and combat with obesity. The studies also found that the classical white adipose tissue can transit to be brown fat tissue, which improves diet-induced obesity. However, how this transition is regulated remains largely unknown. Our study found that the gene of RGC-32 is important for this transition. It suppresses beta-adrenergic receptor expression through activating Akt signaling to inhibit fat tissue thermogenic gene expression. Therefore, RGC-32 may serve as a novel therapeutic target for treating obesity or its related metabolic diseases.

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