EGFR-mediated matrix metalloproteinase-7 up-regulation promotes epithelial–mesenchymal transition via ERK1-AP1 axis during ovarian endometriosis progression

Kasturi Chatterjee, Sayantan Jana, Pramathes DasMahapatra, Snehasikta Swarnakar
  • The FASEB Journal, August 2018, Federation of American Societies For Experimental Biology (FASEB)
  • DOI: 10.1096/fj.201701382rr

Endometriotic cells undergo cellular transition during late stages of ovarian endometriosis

What is it about?

Endometriosis, which results in severe pelvic pain and infertility, affects almost 10% of reproductive women worldwide. It is believed to a benign gynecological disease, however somehow is associated with ovarian cancer development. In this study, we investigated the possible mechanism for the transformation of the disease.

Why is it important?

Our study found that endometriotic epithelial cells undergo cellular transition, which is known as epithelial to mesenchymal transition, during severe stages of the disease. The transition is mediated through a metalloproteinase, known as MMP-7 via EGFR signaling pathways. Inhibition of the specific enzyme can regress the disease as well as inhibit the cellular transitions.



The managements of endometriosis are limited to hormonal therapies and surgeries. We hope our study can translate into clinical practices to help the affected women.

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