Events associated with pregnancy establishment
What is it about?
Epithelial-mesenchymal transition (EMT), often seen in cancer metastasis, is required for conceptus implantation to the maternal endometrium. We have shown for the first time that transcription factor OVOL2 is involved in the regulation of EMT events when conceptuses adhere to the endometrium.
Why is it important?
It was thought that EMT occurs before conceptus attachment to the endometrial epithelium. We have demonstrated that EMT occurs after the initial conceptus attachment to the endometrium and down-regulation of OVLO2 contributes to EMT to proceed.
The following have contributed to this page: Kazuhiko Imakawa
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