MiRNA‘s protection of Blood-brain Barrier by targeting pericytes
What is it about?
Blood–brain barrier (BBB) disruption caused by reperfusion injury after ischemic stroke is an intractable event conducive to further injury. Brain pericytes play a vital role in maintaining BBB integrity by interacting with other components of the BBB. This study targets pericytes to explore new strateges for assessment and treatment for BBB injury induced by cerebral ischemia/reperfusion.
Why is it important?
Our findings show that miR-149-5p could alleviate BBB permeability by targeting S1PR2 of pericytes after acute cerebral ischemia/reperfusion injury in rats. Our data suggest that miR-149-5p may serve as a potential target for assessment and treatment of BBB disruption after ischemic stroke.
The following have contributed to this page: Yan Wan
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