MicroRNA-149-5p regulates blood–brain barrier permeability after transient middle cerebral artery occlusion in rats by targeting S1PR2 of pericytes

Yan Wan, Hui-Juan Jin, Yi-Yi Zhu, Zhi Fang, Ling Mao, Quanwei He, Yuan-Peng Xia, Man Li, Yanan Li, Xiaoqian Chen, Bo Hu
  • The FASEB Journal, June 2018, Federation of American Societies For Experimental Biology (FASEB)
  • DOI: 10.1096/fj.201701121r

MiRNA‘s protection of Blood-brain Barrier by targeting pericytes

What is it about?

Blood–brain barrier (BBB) disruption caused by reperfusion injury after ischemic stroke is an intractable event conducive to further injury. Brain pericytes play a vital role in maintaining BBB integrity by interacting with other components of the BBB. This study targets pericytes to explore new strateges for assessment and treatment for BBB injury induced by cerebral ischemia/reperfusion.

Why is it important?

Our findings show that miR-149-5p could alleviate BBB permeability by targeting S1PR2 of pericytes after acute cerebral ischemia/reperfusion injury in rats. Our data suggest that miR-149-5p may serve as a potential target for assessment and treatment of BBB disruption after ischemic stroke.

Perspectives

Yan Wan (Author)
Huazhong University of Science and Technology

I hope this article makes more people understand the efforts we make to diagnose and treat ischemic stroke. The BBB disruption is common after stroke, and causes diverse injuries. We focus on pericytes to explore the mechanisms. More than anything else, and if nothing else, I hope you find this article thought-provoking.

Read Publication

http://dx.doi.org/10.1096/fj.201701121r

The following have contributed to this page: Yan Wan