What is it about?
Blood flow to the pregnant uterus and developing embryo is essential for healthy pregnancy outcomes. We show disorders of uterine angiogenesis and dysregulated signaling in the placenta contribute to preeclampsia in a genetic mouse model of preeclampsia.
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Why is it important?
Discovering the cause of abnormal uterine angiogenesis can help prevent adverse pregnancy outcomes and ultimately save the lives of mother and baby.
Perspectives
Preeclampsia is a pregnancy specific disorder with an unknown origin. Using a genetic mouse model that spontaneously develops preeclampsia, we have elucidated potential uterine origins of this disorder and pinpointed them to a specific time when angiogenesis of the pregnant uterus is critical.
Jenny Sones
Colorado State University
Read the Original
This page is a summary of: Angiogenic factor imbalance precedes complement deposition in placentae of the BPH/5 model of preeclampsia, The FASEB Journal, January 2018, Federation of American Societies For Experimental Biology (FASEB), DOI: 10.1096/fj.201701008r.
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