Staphylococcus aureus triggers a shift from influenza virus–induced apoptosis to necrotic cell death

Andre van Krüchten, Janine J. Wilden, Silke Niemann, Georg Peters, Bettina Löffler, Stephan Ludwig, Christina Ehrhardt
  • The FASEB Journal, January 2018, Federation of American Societies For Experimental Biology (FASEB)
  • DOI: 10.1096/fj.201701006r

What is it about?

Staphylococcus aureus (S. aureus) cause major complications in influenza virus (IV) infected patients. van Krüchten et al. reveal a possible mechanism, which contributes to higher pathogenicity in super-infected individuals. S. aureus inhibits the IV-induced cellular apoptotic response and triggers an agr-dependent switch to necrosis correlating to enhanced cell damage.

The following have contributed to this page: Christina Ehrhardt and Stephan Ludwig