Western diet linked to brain inflammation and reduced neuroplasticity and memory impairment.
What is it about?
Long-term consumption of Western diet changes specific bile acids and gut bacteria that are associated with the cause of brain inflammation and memory loss. In addition, Western diet-fed mice had increased inflammation in liver, ileum, adipose tissue, and spleen. In the brain as well as the digestive tract, Western diet reduced retinoic acid and bile acid signaling, whose receptors linked together and can control metabolism and inflammation. Mice fed with Western diet have developed several changes in the central nervous system that were associated with inflammation, elevated potassium channel expression in microglia, synaptic degeneration, and reduced neurotrophism.
Why is it important?
The study is timely due to the prevalence of high fat and high sugar Western diet-induced metabolic syndrome associated dementia-related Alzheimer’s disease. “Through gut-brain axis, Western diet driven changes in bile acid profile and gut microbiota dysbiosis can cause brain inflammation and cognitive decline”.
The following have contributed to this page: Prasant Jena and Yu-Jui Yvonne Wan Wan
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