Beta-actin impact on the nuclear genome organization, transcription programs.
What is it about?
Using beta-actin knockout Mouse Embryonic Fibroblasts, we showed the changes in the heterochromatin organization, which is associated with dramatic changes in genes involved in common cellular processes. Those gene programs changes lead to differential phenotypical cellular identity.
Why is it important?
This study highlighted the importance of beta-actin especially in the nucleus to influence the chromatin organization and gene programs. This implies an essential function of beta-actin in the establishment of cell fate and identity.
The following have contributed to this page: Dr Piergiorgio Percipalle and Xin Xie
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