Causes and consequences of tetraploidy in cancer cells
What is it about?
Understanding the consequences of whole genome duplication (i.e., tetraploidization) on genome stability and the phenotype of cancer cells. We address two major questions: 1) what cellular mechanisms involved in controlling the stability of the genome are affected upon tetraploidization, and 2) what benefit does the cancer cell obtain from whole genome duplication. This study shows that replication stress is triggered by polyploidization, suggesting a novel role of replication stress during tumor progression.
Why is it important?
This study sheds new light on understanding the causes of one of the major hallmarks of cancer, i.e., genomic instability. Replication stress is associated, not only with structural aberrations, but also with numerical chromosome alterations, i.e., aneuploidy.
The following have contributed to this page: Amaia Ercilla and Jordi Camps
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