Space microgravity drives transdifferentiation of human bone marrow–derived mesenchymal stem cells from osteogenesis to adipogenesis

Cui Zhang, Liang Li, Yuanda Jiang, Cuicui Wang, Baoming Geng, Yanqiu Wang, Jianling Chen, Fei Liu, Peng Qiu, Guangjie Zhai, Ping Chen, Renfu Quan, Jinfu Wang
  • The FASEB Journal, August 2018, Federation of American Societies For Experimental Biology (FASEB)
  • DOI: 10.1096/fj.201700208rr

The effect of microgravity on mesenchymal stem cells

What is it about?

The objective of this space experiment is to study the effects of microgravity on the osteogenic differentiation potentials and molecule mechanisms as well as the key cell signaling molecules specific for osteogenic differentiation. These studies may provide certain scientific basis for overcoming the bone loss during space exploration and developing the targeted drugs. This project is the first research on the molecule mechanisms specific for osteogenic differentiation of mesenchymal stem cells.

Why is it important?

Simulated microgravity remains a controversial substitute for real microgravity. In this study, we examined the effects of real space microgravity on the differentiation potential of hMSCs and analyzed the molecular mechanisms underlying these effects in the space microgravity environment of the SJ-10 Recoverable Scientific Satellite.

Perspectives

Cui Zhang (Author)
Zhejiang University

This manuscript can promote the study for the biological effects of microgravity on bone cell formation and the relative molecular mechanisms in stem cell level, which is one of the important subjects to explore the effects of spatial microgravity on bone changes. These studies may provide a scientific basis for the development and the related technologies of target drugs research.

Read Publication

http://dx.doi.org/10.1096/fj.201700208rr

The following have contributed to this page: Jinfu Wang, yanqiu wang, and Cui Zhang