Space microgravity drives transdifferentiation of human bone marrow–derived mesenchymal stem cells from osteogenesis to adipogenesis

Cui Zhang, Liang Li, Yuanda Jiang, Cuicui Wang, Baoming Geng, Yanqiu Wang, Jianling Chen, Fei Liu, Peng Qiu, Guangjie Zhai, Ping Chen, Renfu Quan, Jinfu Wang
  • The FASEB Journal, March 2018, Federation of American Societies For Experimental Biology (FASEB)
  • DOI: 10.1096/fj.201700208rr

What is it about?

The objective of this space experiment is to study the effects of microgravity on the osteogenic differentiation potentials and molecule mechanisms as well as the key cell signaling molecules specific for osteogenic differentiation. These studies may provide certain scientific basis for overcoming the bone loss during space exploration and developing the targeted drugs. This project is the first research on the molecule mechanisms specific for osteogenic differentiation of mesenchymal stem cells.

The following have contributed to this page: Jinfu Wang

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