What is it about?
Dendritic cells are engineered to de novo produce a high concentration of he active vitamin D metabolite. We have shown that such engineered dendritic cells, when loaded with a myelin antigen and administered in vivo, can augment the induction of myelin-specific regulatory T cells for myelin-specific suppression of inflammation in the central nervous system.
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Why is it important?
Specific suppression of the demyelinating inflammation without causing unintended immune suppression is one ideal therapy for multiple sclerosis. In this regard, our novel therapeutic strategy may help this achieve this goal in the near future.
Perspectives
It was a great pleasure working with a group co-authors whose hard work made this publication possible.
Xiaolei Tang
Loma Linda University
Read the Original
This page is a summary of: Dendritic cells, engineered to overexpress 25-hydroxyvitamin D 1α-hydroxylase and pulsed with a myelin antigen, provide myelin-specific suppression of ongoing experimental allergic encephalomyelitis, The FASEB Journal, March 2017, Federation of American Societies For Experimental Biology (FASEB),
DOI: 10.1096/fj.201601243r.
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