What is it about?
To get better understanding of the antimetastatic gene nm23-1 we explored accute oxidative stress response in mice invalidated for the gene. We showed that nm23-1 was protective by limiting stress response signals in the liver and skin cells and in the conjonctive tissue cells, fibroblats.
Featured Image
Why is it important?
Nm23-1 gene was the first anti-metastatic gene identified in the late 80's. It belongs to a family of genes involved in the synthesis of nucleotides, the bricks for nucleic acid synthesis in the cells. However, it has other roles in the cell, in particular by nucleotide substrate channeling, regulating kinases functions. We showed here that in response to stress, it controls the kinases stress responses.
Perspectives
We had found before that the physiological role of nm23-1 was mainly important during baby lactation because its absence impaired proper nipple maturation. Otherwise, the invalidated mice didn't show any major dysfunction. It was important to access to reveal the gene impact on situations other than cancer.
sandrine dabernat
Universite de Bordeaux
Read the Original
This page is a summary of: Metastasis suppressor NM23 limits oxidative stress in mammals by preventing activation of stress-activated protein kinases/JNKs through its nucleoside diphosphate kinase activity, The FASEB Journal, January 2017, Federation of American Societies For Experimental Biology (FASEB),
DOI: 10.1096/fj.201600705r.
You can read the full text:
Contributors
The following have contributed to this page
