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The meiotic strand exchange reaction driven by Rad51 and Dmc1 is supported by a group of ancillary factors, called mediators. These promote Mus81-dependent crossover formation during meiosis by counteracting the synthesis-dependent strand annealing and branch migration capabilities of the DNA helicases Fml1 and Rqh1.
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This page is a summary of: Rad51/Dmc1 paralogs and mediators oppose DNA helicases to limit hybrid DNA formation and promote crossovers during meiotic recombination, Nucleic Acids Research, November 2014, Oxford University Press (OUP),
DOI: 10.1093/nar/gku1219.
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